Article

The SH3BGRL protein family nucleates and caps actin filaments via its conserved thioredoxin fold

2025-03-25

Abstract excerpt

Cellular actin polymerization is a tightly regulated process, typically controlled by proteins with specialized domains such as the Wiskott-Aldrich syndrome protein homology 2 (WH2) domain. Here, we identify SH3BGRL family proteins as modulators of actin dynamics, uniquely characterized by their thioredoxin (Trx) fold structure and the absence of the canonical CXXC enzymatic site essential for redox activity. The...

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Literature Corpus work: 56f7e488-64c3-5fdc-92fb-14c53171fc4c
DOI: 10.1101/2025.03.25.645244

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