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The Landscape of Tumor Fusion Neoantigens: A Pan-Cancer Analysis

18 Oct 2019

Abstract excerpt

Compared with SNV&indel-based neoantigens, fusion-based neoantigens are not well characterized. In the present study, we performed a comprehensive analysis of the landscape of tumor fusion neoantigens in cancer and proposed a score scheme to quantitatively assess their immunogenic potentials. By analyzing three large-scale tumor datasets, we demonstrated that (1) the tumor fusion candidate neoantigen burden is...

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PMID: 31677477
DOI: 10.1016/j.isci.2019.10.028

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