Article

Rational Design of Aptamer Switches with Programmable pH Response

2020-03-16

Abstract excerpt

Aptamer switches that respond sensitively to local variations in pH could enable the development of molecular devices that greatly enhance diagnostic accuracy and therapeutic efficacy. Previous design strategies relied on inserting a known pH-sensitive DNA motif into the aptamer structure. Unfortunately, their performance was ultimately governed by the intrinsic pH-response of the inserted motif and could not be r...

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Literature Corpus work: 56f05831-9b14-5c85-86ea-e24477094239
DOI: 10.1101/2020.03.14.992040

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