Article

Mitochondrial adenine base editing of mouse somatic tissues via adeno-associated viral delivery

2024-12-13

Abstract excerpt

The development of adenine base editing in mitochondria, alongside cytidine base editing, has significantly expanded the genome engineering capabilities of the mitochondrial DNA. We tested the recent advancements in adenine base editing technology using optimised TALEs targeting genes Mt-Cytb, Mt-CoII and Mt-Atp6 in mouse cells, and observed successful A:T to G:C conversions within the target windows of each gen...

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Identifiers and source

Literature Corpus work: 56ecf839-3371-571b-b2f2-032a60c9fd27
DOI: 10.1101/2024.12.10.627690

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