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Article

In vivo mitochondrial base editing via adeno-associated viral delivery to mouse post-mitotic tissue.

Nature communications - 8 Feb 2022

Silva-Pinheiro Pedro, Nash Pavel A, Van Haute Lindsey, Mutti Christian D, Turner Keira, Minczuk Michal

Abstract excerpt

Mitochondria host key metabolic processes vital for cellular energy provision and are central to cell fate decisions. They are subjected to unique genetic control by both nuclear DNA and their own multi-copy genome - mitochondrial DNA (mtDNA). Mutations in mtDNA often lead to clinically heterogeneous, maternally inherited diseases that display different organ-specific presentation at any stage of life. For a long...

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Identifiers

PMID: 35136065
DOI: 10.1038/s41467-022-28358-w
PMCID: PMC8825850

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