Article

Dual targeting of NF-κB and JAK-STAT pathways by pinoresinol attenuates IL-6-mediated inflammation in differentiated THP-1 cells

2024-02-12

Abstract excerpt

<title>Abstract</title><p><italic><bold>Background:</bold></italic>Dysregulated synthesis of IL-6 plays a critical role in inflammation-induced disease pathophysiology. IL-6 is known to induce NF-κB alongside canonical JAK-STAT pathway, indicating the importance of cascade proteins of these two pathways as the targets of anti-inflammatory compounds. Plant-derived phenolic compounds are acknowledged as for their an...

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Literature Corpus work: 364db207-eeec-52b0-8517-1734840bf9a1
DOI: 10.21203/rs.3.rs-3937674/v1

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