Article

Pinoresinol targets NF-κB alongside STAT3 pathway to attenuate IL-6-induced inflammation

2024-01-18

Abstract excerpt

<h4>Objective: </h4> Activation of NF-κB alongside STAT3 by IL-6 plays major role in inflammation-induced disease pathophysiology. Here, we report the mechanism of downregulation of NF-κB and JAK-STAT pathways by pinoresinol in IL6-induced macrophages. Methods Bioinformatic analysis screened Pinoresinol, among 100 dietary polyphenols, as the most potent to interact with the proteins in NF-κB and JAK-STAT cascades...

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Literature Corpus work: 2b7d8b01-cc4a-5892-bc44-a509ea7e2444
DOI: 10.21203/rs.3.rs-3857851/v1

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