Article

Pinoresinol targets NF-kB alongside STAT3 pathway to attenuate IL-6-induced inflammation

2024-01-30

Abstract excerpt

Dysregulated synthesis of IL-6 plays a critical role in inflammation-induced disease pathophysiology. IL-6 is known to induce NF-κB along with canonical JAK-STAT pathway, indicating the importance of cascade proteins of these two pathways as the targets of anti-inflammatory compounds. Here, we report the mechanism of downregulation of NF-κB and JAK-STAT pathways by pinoresinol, a plant lignan, in IL6-induced macro...

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Literature Corpus work: 4468f6c6-801e-5b06-ae4b-71c5766d1734
DOI: 10.21203/rs.3.rs-3900297/v1

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