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New coumarin-piperazine derivatives alleviate inflammatory bowel diseases as IL-6 inhibitors by targeting NF-κB pathway

2026-07-14

Abstract excerpt

<title>Abstract</title> <p> Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disease that is difficult to cure. In present work, a series of new coumarin-piperazine derivatives have been designed and prepared, and their anti-inflammatory activities and mechanism have been investigated. The results revealed that some compounds showed excellent inhibition effect on NO generation with low IC <...

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Literature Corpus work
55d85723-25d2-5a01-8ac6-ea8536f73bc1
DOI
10.21203/rs.3.rs-10278709/v1
Open publication

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