Article

How to improve polygenic prediction from whole-genome sequencing data by leveraging predicted epigenomic features?

2024-10-06

Abstract excerpt

Polygenic risk scores (PRS) are crucial in genetics for predicting individual susceptibility to complex diseases by aggregating the effects of numerous genetic variants. Whole-genome sequencing (WGS) has revolutionized our ability to detect rare and even de novo variants, creating an exciting opportunity for developing new PRS methods that can effectively leverage rare variants and capture the complex relationship...

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Literature Corpus work: 5691809b-a77d-53f7-809c-5288863ed945
DOI: 10.1101/2024.10.04.24314860

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