Article

CREATE: cell-type-specific cis-regulatory elements identification via discrete embedding

2024-10-03

Abstract excerpt

Identifying cis-regulatory elements (CREs) within non-coding genomic regions—such as enhancers, silencers, promoters, and insulators—is pivotal for elucidating the intricate gene regulatory mechanisms underlying complex biological traits. The current prevalent sequence-based methods often focus on singular CRE types, limiting insights into cell-type-specific biological implications. Here, we introduce CREATE, a mu...

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Literature Corpus work: 0a02829e-1a20-5a10-91dc-7e7f16a439e6
DOI: 10.1101/2024.10.02.616391

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