Article

PPARγ regulates PNPLA3 in adipocytes in vitro and in vivo in healthy obese patients and mice with metabolic dysfunction-associated steatohepatitis

2024-08-09

Abstract excerpt

<title>Abstract</title> <p>The mechanisms regulating the patatin-like phospholipase domain-containing protein 3 (PNPLA3) are currently unclear. We uncovered that peroxisome proliferator-activated receptor gamma (PPARγ) transcriptionally regulates PNPLA3 <italic>in vitro</italic> and <italic>in vivo</italic> in humans and diabetic and hyperlipidaemic mice. We observed increased <italic>PNPLA3</italic> mRNA transcr...

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Literature Corpus work: 5675a84b-567d-5ff0-bde0-40310cf39119
DOI: 10.21203/rs.3.rs-4585932/v1

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