Article

Intra-host IRES heterogeneity shapes hepatitis C virus translation through epistatic and population-level effects

2026-08-09

Abstract excerpt

Hepatitis C virus (HCV) circulates within each patient as a diverse population of closely related genomes, yet RNA functional properties are commonly inferred from a single consensus or dominant genome. The contribution of non-coding intra-host variability, particularly within the internal ribosome entry site (IRES), to translational efficiency remains poorly defined. Here we investigated how naturally occurring H...

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Literature Corpus work: 5669caf9-b3fc-5dfb-b533-e93b08e35502
DOI: 10.64898/2026.08.05.743084

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