Article

Favipiravir antiviral efficacy against SARS-CoV-2 in a hamster model

2020-07-07

Abstract excerpt

Despite no or limited pre-clinical evidence, repurposed drugs are massively evaluated in clinical trials to palliate the lack of antiviral molecules against SARS-CoV-2. Here we used a Syrian hamster model to assess the antiviral efficacy of favipiravir, understand its mechanism of action and determine its pharmacokinetics. When treatment was initiated before or simultaneously to infection, favipiravir had a strong...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cdf96343-1c77-58c7-8534-7e2c29182fa8
DOI: 10.1101/2020.07.07.191775

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Favipiravir antiviral efficacy against SARS-CoV-2 in a hamster modelDOI 10.1101/2020.07.07.191775Read

The combined treatment of Molnupiravir and Favipiravir results in a marked potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection modelSemantic proximity Read

Molnupiravir Inhibits Replication of the Emerging SARS-CoV-2 Variants of Concern in a Hamster Infection Model.Semantic proximity Read

Genetic consequences of effective and suboptimal dosing with mutagenic drugs in a hamster model of SARS-CoV-2 infectionSemantic proximity Read

Genetic consequences of effective and suboptimal dosing with mutagenic drugs in a hamster model of SARS-CoV-2 infectionSemantic proximity Read

Potential use of RNA-dependent RNA polymerase (RdRp) inhibitors against SARS-CoV2 infectionSemantic proximity Read

Tissue protective role of Ganetespib in SARS-CoV-2-infected Syrian golden hamstersSemantic proximity Read

Favipiravir, umifenovir and camostat mesylate: a comparative study against SARS-CoV-2Semantic proximity Read

Therapeutic effects of favipiravir against severe fever with thrombocytopenia syndrome virus infection in a lethal mouse model: dose-efficacy studies upon oral administrationSemantic proximity Read

Integrated <i>in vivo</i> and transcriptomic analyses of lethal Oropouche virus infection reveal suppression of pathogenic host responses by antiviral therapySemantic proximity Read

A single-administration therapeutic interfering particle reduces SARS-CoV-2 viral shedding and pathogenesis in hamstersSemantic proximity Read

Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in miceSemantic proximity Read

The small molecule inhibitor of SARS-CoV-2 3CLpro EDP-235 prevents viral replication and transmission in vivoSemantic proximity Read