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Article

Epitope-Focused Immunogens Confer Broad Protection against Coronaviruses

2026-08-04

Abstract excerpt

<h4>ABSTRACT</h4> Variable regions in coronavirus spike dominate antibody responses elicited by infection or conventional vaccination and limit induction of broad neutralization. In contrast, conserved S2 elements, including the stem helix (SH) and fusion peptide proximal region (FPPR), are promising but subdominant targets of protective immunity. Here, we employed computational design to generate de novo epitop...

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Literature Corpus work
041f837c-ddc9-5218-b0de-b2fc82282a91
DOI
10.64898/2026.08.02.742375
Open publication

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Epitope-Focused Immunogens Confer Broad Protection against CoronavirusesDOI 10.64898/2026.08.02.742375
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