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Design of SARS-CoV-2 RBD immunogens to focus immune responses toward conserved coronavirus epitopes

13 Jun 2025

Abstract excerpt

SARS-CoV-2 continues to evolve, with new variants emerging that evade pre-existing immunity and limit the efficacy of existing vaccines. One approach toward developing superior, variant-proof vaccines is to engineer immunogens that preferentially elicit antibodies with broad cross-reactivity against SARS-CoV-2 and its variants by targeting conserved epitopes on spike. The inner and outer faces of the receptor...

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PMID: 40511920
DOI: 10.1128/jvi.00465-25

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