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Anti-MDA5 monoclonal antibodies from patients with dermatomyositis - B cell characteristics and differential targeting of the helicase domains

2025-12-02

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objectives</h4> Autoantibodies targeting melanoma differentiation associated protein 5 (MDA5) are strongly associated with dermatomyositis (DM) and may contribute to its pathogenesis. Here we aimed to investigate MDA5 + B cells, their phenotype and generate MDA5 monoclonal antibodies to assess their epitope specificity. <h4>Methods</h4> MDA5-reactive B cells were captured from peripheral...

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Literature Corpus work
55f6f607-0992-5194-85cf-ba800571b169
DOI
10.64898/2025.12.01.691530
Open publication

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Anti-MDA5 monoclonal antibodies from patients with dermatomyositis - B cell characteristics and differential targeting of the helicase domainsDOI 10.64898/2025.12.01.691530
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