Comparative B cell epitope profiling in Japanese and North American cohorts of MDA5+ dermatomyositis patients reveals a direct association between immune repertoire and pulmonary mortality

Abstract excerpt

OBJECTIVES: Anti-melanoma differentiation-associated gene 5 antibody-positive (MDA5+) DM patients exhibit clinical features that vary by geographical and ethnic/genetic distribution. The objective of this study was to investigate whether B cell epitope profiles and corresponding clinical features distinguished two independent cohorts of MDA5+ DM. METHODS: ELISA-based methods were used to determine the...

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