Article

Functional expression of voltage-gated sodium channels in human colorectal cancers in vitro : role in invasiveness

2019-01-01

Abstract excerpt

Functional expression of voltage-gated Na+ channels (VGSCs) occurs in human carcinomas and promotes invasiveness in vitro and metastasis in vivo. Both neonatal and adult forms of Nav1.5 (nNav1.5 and aNav1.5, respectively) have been reported to be expressed at mRNA level in human colorectal cancer (CRCa) cells. The main aims of this PhD on human CRC were (1) to characterise the functional role of the 'neonatal' spl...

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Literature Corpus work: 55e56ef7-0db5-5c12-adad-032932323fba
DOI: 10.25560/86547

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