Article

Structures of wild-type and selected CMT1X mutant connexin 32 gap junction channels and hemichannels

2023-03-10

Abstract excerpt

In myelinating Schwann cells, communication between myelin layers is mediated by gap junction channels (GJC) formed by docked connexin 32 hemichannels (HCs). Mutations in Cx32 cause the X-linked Charcot–Marie–Tooth disease (CMT1X), a degenerative neuropathy with no cure. A molecular link between Cx32 dysfunction and CMT1X pathogenesis is still missing. Here, we describe the high resolution cryo-EM structures of th...

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Literature Corpus work: 2a8b2b5a-9d82-5b97-8559-14cb02045f6a
DOI: 10.1101/2023.03.08.531661

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