Article

Fluximplied: A novel approach integrates rate limiting steps and differential expression for pathway analysis

2022-03-17

Abstract excerpt

<h4>Background</h4> Many tools exist to perform a rigorous pathway analysis, though traditional gene set enrichment analysis remains among the most common. While useful for many applications, one common situation where it is less so is the metabolic profiling of bulk omics datasets. Rate limiting steps in more linear pathways are the main determinant of flux through these pathways, but differential expression of...

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Literature Corpus work: 55cb231c-7df5-5414-86bf-79d4c06f3514
DOI: 10.1101/2022.03.15.484417

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