Article

Investigating the deregulation of metabolic tasks via Minimum Network Enrichment Analysis (MiNEA) as applied to nonalcoholic fatty liver disease using mouse and human omics data

2018-08-28

Abstract excerpt

Nonalcoholic fatty liver disease (NAFLD) is associated with metabolic syndromes spanning a wide spectrum of diseases, from simple steatosis to the more complex nonalcoholic steatohepatitis. To identify the deregulation that occurs in metabolic processes at the molecular level that give rise to these various NAFLD phenotypes, algorithms such as pathway enrichment analysis (PEA) can be used. These analyses require t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d87e019b-0f97-5704-b967-eb027569a788
DOI: 10.1101/402222

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Investigating the deregulation of metabolic tasks via Minimum Network Enrichment Analysis (MiNEA) as applied to nonalcoholic fatty liver disease using mouse and human omics dataDOI 10.1101/402222Read

Lipid network and moiety analysis for revealing enzymatic dysregulation and mechanistic alterations from lipidomics dataSemantic proximity Read

Fluximplied: A novel approach integrates rate limiting steps and differential expression for pathway analysisSemantic proximity Read

Common transcriptional programme of liver fibrosis in mouse genetic models and humansSemantic proximity Read

A strategy to detect metabolic changes induced by exposure to chemicals from large sets of condition-specific metabolic models computed with enumeration techniquesSemantic proximity Read

Differential metabolic activity and discovery of therapeutic targets using summarized metabolic pathway modelsSemantic proximity Read

Pathway analysis in metabolomics: pitfalls and best practice for the use of over-representation analysisSemantic proximity Read

Systematic Analysis of Human Tissue- and Cell-Specific Metabolic Models Identifies High-Sugar, High-Fat Diet–Induced Liver DysregulationSemantic proximity Read

datadrivenhypothesis.org: A resource for metabolic gene discovery through integrated pathway co-essentiality mappingSemantic proximity Read

LIPEA: Lipid Pathway Enrichment AnalysisSemantic proximity Read

MetENP/MetENPWeb: An R package and web application for metabolomics enrichment and pathway analysis in Metabolomics WorkbenchSemantic proximity Read

Correlation guided Network Integration (CoNI) reveals novel genetic regulators of hepatic metabolismSemantic proximity Read

LipidSIM: inferring mechanistic lipid biosynthesis perturbations from lipidomics with a flexible, low-parameter, systematic Markov Modeling frameworkSemantic proximity Read