Article

Single-Nucleus Transcriptomics Reveals Ubiquitin Pathway Dysregulation and Impaired Neuroglial Communication in Chronic Secondhand Smoke-Induced Cognitive Decline

2026-06-05

Abstract excerpt

<title>Abstract</title> <p> Chronic exposure to secondhand smoke (SHS) has been epidemiologically associated with cognitive decline and neurodegenerative disease risk; however, the underlying cellular and molecular mechanisms remain unclear. Here, we established a 54-week-old mouse model of long-term SHS exposure and performed behavioral testing, histological analysis, and single-nucleus RNA sequencing (snRNA-se...

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Literature Corpus work: 55be4cb0-2495-57c9-a849-475b783076c6
DOI: 10.21203/rs.3.rs-9686046/v1

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