Article

Targeting PI3K Signaling for Broad Inhibition of β-Coronavirus Infection

2025-06-23

Abstract excerpt

The phosphatidylinositol 3-kinase (PI3K) signaling pathway plays a central role in regulating key cellular processes such as survival, metabolism, and immune responses. Aberrant activation of this pathway is associated with tumorigenesis, and several PI3K inhibitors have been developed as anticancer agents. Emerging evidence suggests that viruses, including β-coronaviruses, have evolved mechanisms to exploit host...

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Literature Corpus work: 559c7576-0e29-5e23-ae4e-a8668487d5eb
DOI: 10.1101/2025.06.22.660949

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