Article

PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2

2024-04-17

Abstract excerpt

In search for broad-spectrum antivirals, we discovered a small molecule inhibitor, RMC-113, that potently suppresses the replication of multiple RNA viruses including SARS-CoV-2 in human lung organoids. We demonstrated selective dual inhibition of the lipid kinases PIP4K2C and PIKfyve by RMC-113 and target engagement by its clickable analog. Advanced lipidomics revealed alteration of SARS-CoV-2-induced phosphoinos...

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Literature Corpus work: 67f9c9e7-0723-53f3-900e-73ea36c09546
DOI: 10.1101/2024.04.15.589676

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