Article

Trisomy 21 Impairs Development of Enteric Neural Crest-Derived Cells via SOD1-Mediated RET Dysregulation

2026-07-01

Abstract excerpt

<h4>ABSTRACT</h4> Hirschsprung disease (HSCR) is a rare congenital disorder of the enteric nervous system (ENS), marked by the absence of enteric ganglia along variable lengths of the distal gastrointestinal tract, resulting in functional intestinal obstruction. Individuals with Trisomy 21 (Down syndrome) face a 50- to 100-fold increased risk of HSCR relative to the general population, yet the molecular basis of...

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Literature Corpus work: 55596b2e-0d2b-51d0-a08c-42f97de84907
DOI: 10.64898/2026.06.30.735397

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