Article

Systematic identification of host factors influencing human cytomegalovirus replication

2019-01-01

Abstract excerpt

A high-throughput two-step siRNA screen was performed to identify novel host factors required during human cytomegalovirus (HCMV) replication. Almost 7,000 cellular genes were targeted by the siRNA library and 81 candidates, of which gene depletion led to a 50% decrease or 25% increase in virus production, were identified. Functional annotation clustering by STRING revealed functional clusters in mediator complex,...

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Literature Corpus work: 5516f3dd-1877-5420-b43d-f24ac7a72cad
DOI: 10.7488/era/68

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