Article

A virally encoded high resolution screen of cytomegalovirus host dependencies

2023-10-30

Abstract excerpt

Genetic screens have transformed our ability to interrogate cellular factor requirements in infection, yet current approaches are limited in their sensitivity, biased towards early stages of infection and provide only simplistic phenotypic information which is often based on infected cell survival. Here, by engineering human cytomegalovirus to express sgRNA libraries directly from the viral genome, we developed a...

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Literature Corpus work: 7a627d1f-03cd-5806-a575-031c7378ef71
DOI: 10.1101/2023.10.30.564793

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