Article

AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer

2024-05-07

Abstract excerpt

Castration resistant prostate cancer (CRPC) remains an incurable disease stage with ineffective treatments options. Here, the androgen receptor (AR) coactivators CBP/p300, which are histone acetyltransferases, were identified as critical mediators of DNA damage repair (DDR) to potentially enhance therapeutic targeting of CRPC. Key findings demonstrate that CBP/p300 expression increases with disease progression and...

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Identifiers and source

Literature Corpus work: 5510d502-952f-585a-a417-77612334e4be
DOI: 10.1101/2024.05.07.592966

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