Article
Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function.
Nature communications - 3 Nov 2021
Kumar Manish, Molkentine David, Molkentine Jessica, Bridges Kathleen, Xie Tongxin, Yang Liangpeng, Hefner Andrew, Gao Meng, Bahri Reshub, Dhawan Annika, Frederick Mitchell J, Seth Sahil, Abdelhakiem Mohamed, Beadle Beth M, Johnson Faye, Wang Jing, Shen Li, Heffernan Timothy, Sheth Aakash, Ferris Robert L, Myers Jeffrey N, Pickering Curtis R, Skinner Heath D
Abstract excerpt
Despite radiation forming the curative backbone of over 50% of malignancies, there are no genomically-driven radiosensitizers for clinical use. Herein we perform in vivo shRNA screening to identify targets generally associated with radiation response as well as those exhibiting a genomic dependency. This identifies the histone acetyltransferases CREBBP/EP300 as a target for radiosensitization in combination with...
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