Article

p300/CBP degradation is required to disable the active AR enhanceosome in prostate cancer

2024-03-30

Abstract excerpt

<h4>Summary</h4> Prostate cancer is an exemplar of an enhancer-binding transcription factor-driven disease. The androgen receptor (AR) enhanceosome complex comprised of chromatin and epigenetic coregulators assembles at enhancer elements to drive disease progression. The paralog lysine acetyltransferases p300 and CBP deposit histone marks that are associated with enhancer activation. Here, we demonstrate that p30...

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Literature Corpus work: d625b040-50bb-5ab3-be1b-075881532559
DOI: 10.1101/2024.03.29.587346

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