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AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer

12 Sept 2024

Abstract excerpt

Castration resistant prostate cancer (CRPC) remains an incurable disease stage with ineffective treatments options. Here, the androgen receptor (AR) coactivators CBP/p300, which are histone acetyltransferases, were identified as critical mediators of DNA damage repair (DDR) to potentially enhance therapeutic targeting of CRPC. Key findings demonstrate that CBP/p300 expression increases with disease progression...

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PMID: 39266679
DOI: 10.1038/s41388-024-03148-4

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