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Nuclear Galectin-1 promotes KRAS -dependent activation of pancreatic cancer stellate cells

2 Apr 2025

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers, primarily due to its complex tumor microenvironment (TME), which drives both disease progression and therapy resistance. Understanding the molecular mechanisms governing TME dynamics is essential for developing new treatment strategies for this devastating disease. In this study, we uncover an oncogenic role for Galectin-1 (Gal1), a...

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PMID: 40172967
DOI: 10.1073/pnas.2424051122

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