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Reimagining antibody-dependent cellular cytotoxicity in cancer: the potential of natural killer cell engagers

27 Oct 2022

Abstract excerpt

Bi-, tri- and multispecific antibodies have enabled the development of targeted cancer immunotherapies redirecting immune effector cells to eliminate malignantly transformed cells. These antibodies allow for simultaneous binding of surface antigens on malignant cells and activating receptors on innate immune cells, such as natural killer (NK) cells, macrophages, and neutrophils. Significant progress with such...

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PMID: 36306739
DOI: 10.1016/j.it.2022.09.007

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