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Amino acid variants of SARS-CoV-2 papain-like protease have impact on drug binding

21 Nov 2022

Abstract excerpt

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused both a health and economic crisis around the world. Its papain-like protease (PLpro) is one of the protein targets utilized in designing new drugs that would aid vaccines in the fight against the virus. Although there are already several potential candidates for a good inhibitor of this protein, the degree of variability of the...

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PMID: 36409737
DOI: 10.1371/journal.pcbi.1010667

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