Article

Potent and Selective Covalent Inhibition of the Papain-like Protease from SARS-CoV-2

2022-07-21

Abstract excerpt

<title>Abstract</title> <p>Direct-acting antivirals are needed to combat coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The papain-like protease (PLpro) domain of Nsp3 from SARS-CoV-2 is essential for viral replication. In addition, PLpro dysregulates the host immune response by cleaving ubiquitin and interferon-stimulated gene 15 protein (ISG...

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Literature Corpus work: 1810bef9-e058-54b1-b094-cca20bf8112a
DOI: 10.21203/rs.3.rs-906621/v2

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