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Article

Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors.

Nature communications - 2 Feb 2021

Osipiuk Jerzy, Azizi Saara-Anne, Dvorkin Steve, Endres Michael, Jedrzejczak Robert, Jones Krysten A, Kang Soowon, Kathayat Rahul S, Kim Youngchang, Lisnyak Vladislav G, Maki Samantha L, Nicolaescu Vlad, Taylor Cooper A, Tesar Christine, Zhang Yu-An, Zhou Zhiyao, Randall Glenn, Michalska Karolina, Snyder Scott A, Dickinson Bryan C, Joachimiak Andrzej

Abstract excerpt

The pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues to expand. Papain-like protease (PLpro) is one of two SARS-CoV-2 proteases potentially targetable with antivirals. PLpro is an attractive target because it plays an essential role in cleavage and maturation of viral polyproteins, assembly of the replicase-transcriptase complex, and disruption of host responses. We report...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33531496
DOI: 10.1038/s41467-021-21060-3
PMCID: PMC7854729

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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