Article
Inactivation of Nxf2 causes defects in male meiosis and age-dependent depletion of spermatogonia.
Developmental biology - 1 Jun 2009
Pan Jieyan, Eckardt Sigrid, Leu N Adrian, Buffone Mariano G, Zhou Jian, Gerton George L, McLaughlin K John, Wang Peijing Jeremy
Abstract excerpt
In eukaryotes, mRNA is actively transported from nucleus to cytoplasm by a family of nuclear RNA export factors (NXF). While yeast harbors only one such factor (Mex67p), higher eukaryotes encode multiple NXFs. In mouse, four Nxf genes have been identified: Nxf1, Nxf2, Nxf3, and Nxf7. To date, the function of mouse Nxf genes has not been studied by targeted gene deletion in vivo. Here we report the generation of...
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