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Article

MFN2 interacts with nuage-associated proteins and is essential for male germ cell development by controlling mRNA fate during spermatogenesis.

Development (Cambridge, England) - 1 Apr 2021

Wang Xiaoli, Wen Yujiao, Zhang Jin, Swanson Grace, Guo Shuangshuang, Cao Congcong, Krawetz Stephen A, Zhang Zhibing, Yuan Shuiqiao

Abstract excerpt

Mitochondria play a crucial role in spermatogenesis and are regulated by several mitochondrial fusion proteins. However, their functional importance associated with their structure formation and mRNA fate regulation during spermatogenesis remains unclear. Here, we show that mitofusin 2 (MFN2), a mitochondrial fusion protein, interacts with nuage-associated proteins (including MIWI, DDX4, TDRKH and GASZ) in mice....

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Source

Identifiers

PMID: 33674260
DOI: 10.1242/dev.196295

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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