Article

Anti-Correlation of KLRG1 and PD-1 Expression in Human Tumor CD8 T Cells

2023-03-05

Abstract excerpt

Recently, combination checkpoint therapy of cancer has been recognized as producing additive as opposed to synergistic benefit due to in part to positively correlated effects. The potential for uncorrelated or negatively correlated therapies to produce true synergistic benefits has been noted. Whereas the inhibitory receptors PD-1, CTLA-4, TIM-3, LAG-3, and TIGIT have been collectively characterized as exhaustion...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 542cf490-a92e-5500-b1d0-15998c767188
DOI: 10.1101/2023.03.01.23286593

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Anti-Correlation of KLRG1 and PD-1 Expression in Human Tumor CD8 T CellsDOI 10.1101/2023.03.01.23286593Read

KLRG1 identifies circulating cytotoxic CD4 T cells with selective anti-tumor function in human cancerSemantic proximity Read

KLRG1-deficient CAR-T cells exhibit superior antitumor efficacy against colorectal cancer cell lines by modulating the ZAP70/ERK signaling axisSemantic proximity Read

Systemic immune dysfunction in cancer patients driven by IL6 and IL8 induction of an inhibitory receptor module in peripheral CD8 <sup>+</sup> T cellsSemantic proximity Read

The EGR2 targets LAG-3 and 4-1BB describe and regulate dysfunctional antigen-specific CD8+ T cells in the tumor microenvironmentSemantic proximity Read

Functions and Clinical Significance of KLRG1 in the Development of Lung Adenocarcinoma and ImmunotherapySemantic proximity Read

PD-1/LAG-3 Dysfunctionality Signatures in Human CancersSemantic proximity Read

Coexpression of Inhibitory Receptors Enriches for Activated and Functional CD8+ T Cells in Murine Syngeneic Tumor ModelsSemantic proximity Read

TIGIT and PD-L1 co-blockade promotes clonal expansion of multipotent, non-exhausted anti-tumor T cells by facilitating costimulationSemantic proximity Read

Sensitive detection of synthetic response to cancer immunotherapy driven by gene paralog pairsSemantic proximity Read

KLRG1 Cell Depletion as a Novel Therapeutic Strategy in Patients with Mature T-Cell Lymphoma SubtypesSemantic proximity Read

PSGL-1 Immune Checkpoint Inhibition for CD4+ T Cell Cancer Immunotherapy.Semantic proximity Read

TIGIT and CD 96: new checkpoint receptor targets for cancer immunotherapySemantic proximity Read