Article

TIGIT and PD-L1 co-blockade promotes clonal expansion of multipotent, non-exhausted anti-tumor T cells by facilitating costimulation

2024-04-26

Abstract excerpt

<title>Abstract</title> <p>Blockade of the immune checkpoints PD-1 and TIGIT has demonstrated activity in mouse tumor models and human cancer patients. Although these coinhibitory receptors can restrict signaling in CD8<sup>+</sup> T cells by regulating their associated costimulatory receptors CD28 and CD226, the functional consequences of combining PD-1 and TIGIT blockade remain poorly characterized. In mouse tu...

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Literature Corpus work: 37c28f46-b8a0-5577-a557-d927825b0ce0
DOI: 10.21203/rs.3.rs-4201684/v1

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