Stochastic modelling of prostate progenitor architecture

Abstract excerpt

Prostate cancer is a significant global health concern. Experimental and clinical research have contributed to the improvement of treatment outcomes dramatically in the past decade. However, much of the structure of the prostate and its constituent cell types remains unclear: observations of phenotypic switching between basal and luminal cells, as well as intermediate cell types between them, make classifying the...

Topics

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• Clonal Evolution
• High-Throughput Nucleotide Sequencing
• Models, Theoretical
• Mutation
• PARP inhibition in cancer therapy
• Prostate Cancer Treatment and Research
• Prostatic Neoplasms
• Protein Degradation and Inhibitors

Identifiers and source

Literature Corpus work

542afef1-da1d-5fe7-9133-c1257b5de276

DOI

10.1101/2025.06.19.660586