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Is high-grade prostatic intraepithelial neoplasia (HGPIN) a reliable precursor for prostate carcinoma? Implications for clonal evolution and early detection strategies.

The Journal of pathology - 1 Apr 2018

Tolkach Yuri, Kristiansen Glen

Abstract excerpt

High-grade prostatic intraepithelial neoplasia (HGPIN) is a documented putative precursor lesion for invasive prostate adenocarcinoma. However, the precise mechanisms of the carcinoma's development from HGPIN are unclear. Many studies have attempted a comparative molecular genetic characterisation of HGPIN and its corresponding carcinoma to study this transformation. However, to date, some HGPIN mimickers, such...

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Adenocarcinoma
Biopsy
Clonal Evolution
Disease Progression
Early Detection of Cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Grading

Predictive Value of Tests

Prostatic Neoplasms

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PMID: 29377129
DOI: 10.1002/path.5045

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