Lineage plasticity in prostate cancer: Looking beyond intrinsic alterations

Abstract excerpt

Emergence of small cell prostate cancer is linked to the plasticity of tumour cells and avoidance of environmental pressures. This process is thought to be reversable, however to-date evidence of this has been demonstrated in small-cell prostate cancer. To study the plasticity of prostate tumours, we look to clinical cohorts of patients covering the spectra of malignancy subtypes and utilise in vitro and in vivo...

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• PARP inhibition in cancer therapy
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