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<i>Loss of miR-9-2</i> Causes Cerebral Hemorrhage and Hydrocephalus by Widespread Disruption of Cell-Type-Specific Neurodevelopmental Gene Networks

2025-08-01

Abstract excerpt

MIR-9-2 is a broadly and highly expressed microRNA in the developing brain and is frequently deleted in 5q14.3 Microdeletion Syndrome, a rare but severe neurodevelopmental disorder. Despite this, little attention has been paid to the unique contributions of MIR-9-2 to neurodevelopment and disease. We find that deletion of this microRNA leads to embryonic cerebral hemorrhages and severe hydrocephalus, while disrup...

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Literature Corpus work
53f7ca51-48e9-5782-b5aa-5db846edbfbd
DOI
10.1101/2025.07.31.668014
Open publication

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<i>Loss of miR-9-2</i> Causes Cerebral Hemorrhage and Hydrocephalus by Widespread Disruption of Cell-Type-Specific Neurodevelopmental Gene NetworksDOI 10.1101/2025.07.31.668014
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