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Article

PCSK9: a key modulator of cardiovascular health.

Circulation research - 14 Mar 2014

Seidah Nabil G, Awan Zuhier, Chrétien Michel, Mbikay Majambu

Abstract excerpt

Since the discovery of proprotein convertase subtilisin kexin 9 (PCSK9) in 2003, this PC has attracted a lot of attention from the scientific community and pharmaceutical companies. Secreted into the plasma by the liver, the proteinase K-like serine protease PCSK9 binds the low-density lipoprotein (LDL) receptor at the surface of hepatocytes, thereby preventing its recycling and enhancing its degradation in...

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Source

Identifiers

PMID: 24625727
DOI: 10.1161/CIRCRESAHA.114.301621

Genes

PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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