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Normalizing the gene dosage of Dyrk1A in a mouse model of Down syndrome rescues several Alzheimer's disease phenotypes.

Neurobiology of disease - 1 Oct 2017

García-Cerro Susana, Rueda Noemí, Vidal Verónica, Lantigua Sara, Martínez-Cué Carmen

Abstract excerpt

The intellectual disability that characterizes Down syndrome (DS) is primarily caused by prenatal changes in central nervous system growth and differentiation. However, in later life stages, the cognitive abilities of DS individuals progressively decline due to accelerated aging and the development of Alzheimer's disease (AD) neuropathology. The AD neuropathology in DS has been related to the overexpression of...

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PMID: 28647555
DOI: 10.1016/j.nbd.2017.06.010

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Normalizing the gene dosage of Dyrk1A in a mouse model of Down syndrome rescues several Alzheimer's disease phenotypes.PMID 28647555Read ↗

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