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Article

Acetyl-CoA flux from the cytosol to the ER regulates engagement and quality of the secretory pathway.

Scientific reports - 21 Jan 2021

Dieterich Inca A, Cui Yusi, Braun Megan M, Lawton Alexis J, Robinson Nicklaus H, Peotter Jennifer L, Yu Qing, Casler Jason C, Glick Benjamin S, Audhya Anjon, Denu John M, Li Lingjun, Puglielli Luigi

Abstract excerpt

Nε-lysine acetylation in the ER is an essential component of the quality control machinery. ER acetylation is ensured by a membrane transporter, AT-1/SLC33A1, which translocates cytosolic acetyl-CoA into the ER lumen, and two acetyltransferases, ATase1 and ATase2, which acetylate nascent polypeptides within the ER lumen. Dysfunctional AT-1, as caused by gene mutation or duplication events, results in severe...

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Identifiers

PMID: 33479349
DOI: 10.1038/s41598-021-81447-6
PMCID: PMC7820588

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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