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Alpha-synuclein aggregation and dopaminergic neuron death in a new mouse model of Parkinson’s disease expressing human full-length and C-terminally truncated 1- 120 alpha-synuclein

2025-04-18

Abstract excerpt

<h4>ABSTRACT</h4> Parkinson’s disease (PD) is neuropathologically characterized by the presence of Lewy bodies and Lewy neurites made of aggregated alpha-synuclein (aSyn). Several studies have shown that Lewy bodies contain C-terminally truncated aSyn which is more prone to fibrillation and enhances the aggregation of human full-length aSyn in vitro . Nevertheless, in vivo studies addressing whether and how hum...

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Literature Corpus work
53a56387-9a8a-5b81-a428-50a7b84e8eb8
DOI
10.1101/2025.04.13.647581
Open publication

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Alpha-synuclein aggregation and dopaminergic neuron death in a new mouse model of Parkinson’s disease expressing human full-length and C-terminally truncated 1- 120 alpha-synucleinDOI 10.1101/2025.04.13.647581
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