Article

Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na <sup>+</sup> channels in nanodisc

2020-04-18

Abstract excerpt

NaChBac, the first bacterial voltage-gated Na + (Na v ) channel to be characterized, has been the prokaryotic prototype for studying the structure-function relationship of Na v channels. Discovered nearly two decades ago, the structure of NaChBac has not been determined. Here we present the cryo-EM analysis of NaChBac in both detergent micelles and nanodiscs. Under both conditions, the conformation of NaChBac i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 539e00e8-ebe3-56ea-a3dc-33f2780a4304
DOI: 10.1101/2020.04.16.045674

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na <sup>+</sup> channels in nanodiscDOI 10.1101/2020.04.16.045674Read

Models of the structure and gating mechanisms of the pore domain of the NaChBac ion channel.Semantic proximity Read

The C-terminal coiled-coil of the bacterial voltage-gated sodium channel NaChBac is not essential for tetramer formation, but stabilizes subunit-to-subunit interactions.Semantic proximity Read

Crystal structure of the extracellular domain of nAChR alpha1 bound to alpha-bungarotoxin at 1.94 A resolution.Semantic proximity Read

The cation selectivity filter of the bacterial sodium channel, NaChBac.Semantic proximity Read

Distance measurements reveal a common topology of prokaryotic voltage-gated ion channels in the lipid bilayer.Semantic proximity Read

Structures of closed and open states of a voltage-gated sodium channel.Semantic proximity Read

Elucidating Molecular Mechanisms of Protoxin-2 State-specific Binding to the Human Na <sub>V</sub> 1.7 ChannelSemantic proximity Read

CryoEM reveals unprecedented binding site for Na <sub>V</sub> 1.7 inhibitors enabling rational design of potent hybrid inhibitorsSemantic proximity Read

Modeling P-loops domain of sodium channel: homology with potassium channels and interaction with ligands.Semantic proximity Read

µ-Conotoxins Modulating Sodium Currents in Pain Perception and TransmissionSemantic proximity Read

Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant.Semantic proximity Read

Mapping allosteric linkage to channel gating by extracellular domains in the human epithelial sodium channel.Semantic proximity Read